Comparative genomic hybridization
METHOD TO EVALUATE BIOLOGICAL SAMPLES
Comparative genomic hybridization (CGH); Array-comparative genomic hybridization; ACGH; Array CGH; Comparative Genomic Hybridization; Comparative Genomic Hybridisation; Comparative hybridization; Array comparative genomic hybridisation; Cot 1 DNA; Cot-1 DNA; Comparative genome hybridization; Chromosomal microarray analysis; CGH array; Array comparative genomic hybridization; Array-comparative Genomic Hybridization; Microarray-based comparative genomic hybridization; A-CGH; Array hybridization
Comparative genomic hybridization (CGH) is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells. The aim of this technique is to quickly and efficiently compare two genomic DNA samples arising from two sources, which are most often closely related, because it is suspected that they contain differences in terms of either gains or losses of either whole chromosomes or subchromosomal regions (a portion of a whole chromosome).