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Wat (wie) is nuclear antigens - definitie

SOLUBLE CYTOPLASMIC AND NUCLEAR COMPONENTS

Extractable Nuclear Antigens; ENA 4; ENA4; Anti-ENA; Extractable nuclear antigens

Extractable nuclear antigen

Extractable nuclear antigens (ENAs) are over 100 different soluble cytoplasmic and nuclear antigens. They are known as "extractable" because they can be removed from cell nuclei using saline and represent six main proteins: Ro, La, Sm, RNP, Scl-70, Jo1.

https://en.wikipedia.org/wiki/Extractable_nuclear_antigen

Proliferating cell nuclear antigen

MAMMALIAN PROTEIN FOUND IN HOMO SAPIENS

PCNA; Proliferating Cell Nuclear Antigen; PCNA (gene)

Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.

https://en.wikipedia.org/wiki/Proliferating_cell_nuclear_antigen

Epstein–Barr virus nuclear antigen 2

VIRAL NUCLEAR PROTEIN

EBNA-2; EBV nuclear antigen 2; Epstein-Barr virus nuclear antigen 2

The Epstein–Barr virus nuclear antigen 2 (EBNA-2) is one of the six EBV viral nuclear proteins expressed in latently infected B lymphocytes is a transactivator protein. EBNA2 is involved in the regulation of latent viral transcription and contributes to the immortalization of EBV infected cells.

https://en.wikipedia.org/wiki/Epstein–Barr_virus_nuclear_antigen_2

Wikipedia

Extractable nuclear antigen

Extractable nuclear antigens (ENAs) are over 100 different soluble cytoplasmic and nuclear antigens. They are known as "extractable" because they can be removed from cell nuclei using saline and represent six main proteins: Ro, La, Sm, RNP, Scl-70, Jo1. Most ENAs are part of spliceosomes or nucleosomes complexes and are a type of small nuclear ribonucleoprotein (snRNPS). The location in the nucleus and association with spliceosomes or nucleosomes results in these ENAs being associated with additional RNA and proteins such as polymerases. This quality of ENAs often makes it difficult to purify and quantify their presence for clinical use.

https://en.wikipedia.org/wiki/Extractable nuclear antigen