purine ; 5"; nucleotidase - definitie. Wat is purine ; 5"; nucleotidase
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Wat (wie) is purine ; 5"; nucleotidase - definitie

INTERPRO FAMILY
EC 3.1.3.5; Uridine 5'-nucleotidase; 5'-adenylic phosphatase; Adenosine 5'-phosphatase; AMP phosphatase; Adenosine monophosphatase; 5'-mononucleotidase; AMPase; UMPase; Snake venom 5'-nucleotidase; Thimidine monophosphate nucleotidase; 5'-AMPase; 5'-AMP nucleotidase; AMP phosphohydrolase; IMP 5'-nucleotidase; 5'-ribonucleotide phosphohydrolase

NT5E         
MAMMALIAN PROTEIN FOUND IN HOMO SAPIENS
CD73; NT5E (gene); Ecto-5'-nucleotidase
5′-nucleotidase (5′-NT), also known as ecto-5′-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine.
Purine metabolism         
THE CHEMICAL REACTIONS AND PATHWAYS INVOLVING PURINE NUCLEOTIDES
Purine biosynthesis; Purine degradation; Purine synthesis inhibitors; Purine inhibitors; Purine synthesis inhibitor; Adenine pathway
Purine metabolism refers to the metabolic pathways to synthesize and break down purines that are present in many organisms.
purine         
  • The main purine-derived [[nucleobase]]s.
CHEMICAL COMPOUND
Purines; Purine nucleotides; Purine nucleosides; Traube purine synthesis; 7H-purine; C1=C2C(=NC=N1)N=CN2
['pj??ri:n]
¦ noun Chemistry a colourless crystalline bicyclic compound with basic properties.
?(also purine base) a substituted derivative of this forming one of the two classes of base present in DNA and RNA, including adenine and guanine.
Origin
C19: from Ger. Purin, from L. purus 'pure' + uricum 'uric acid' (which it forms on oxidation) + -ine4.

Wikipedia

5'-nucleotidase

5′-Nucleotidase (EC 3.1.3.5) is an enzyme which catalyzes the phosphorylytic cleavage of 5′-nucleotides. Although originally found in snake venom, the activity of 5'nucleotidase has been described for bacteria and plant cells, and is widely distributed in vertebrate tissue. In mammalian cells the enzyme is predominantly located in the plasma membrane and its primary role is in the conversion of extracellular nucleotides (e.g. 5'-AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. Consequently, the enzyme plays a key role in the metabolism of nucleotides.

The enzyme has a wide substrate specificity for nucleotides and has been shown to hydrolyze 5'nucleotides rapidly, ribose-5-phosphate slowly, and other phosphate esters extremely slowly (if at all).

The enzyme catalyses the following reaction:

a 5′-nucleotide + H2O ⇌ a nucleoside + phosphate

The 5′-nucleotidase-catalyzed reaction of an AMP nucleotide to adenosine nucleoside is shown below: