thrombokinase - vertaling naar frans
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thrombokinase - vertaling naar frans

MAMMALIAN PROTEIN FOUND IN HOMO SAPIENS
Thrombokinase; Stuart-Prower factor; Factor Xa; Factor x; Coagulation factor Xa; Factor xa; Factor x deficiency; Coagulation factor X; FXA; Fxa; Stuart factor; F10 (gene); EC 3.4.21.6; Coagadex; Coagulation factor X (human)
  • Blood coagulation pathways ''in vivo'' showing the central role played by thrombin

thrombokinase      
n. thrombokinase, substance found in blood platelets and used to stop bleeding

Wikipedia

Factor X

Factor X, also known by the eponym Stuart–Prower factor, is an enzyme (EC 3.4.21.6) of the coagulation cascade. It is a serine endopeptidase (protease group S1, PA clan). Factor X is synthesized in the liver and requires vitamin K for its synthesis.

Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as intrinsic tenase) and factor VII with its cofactor, tissue factor (a complex known as extrinsic tenase). It is therefore the first member of the final common pathway or thrombin pathway.

It acts by cleaving prothrombin in two places (an arg-thr and then an arg-ile bond), which yields the active thrombin. This process is optimized when factor Xa is complexed with activated co-factor V in the prothrombinase complex.

Factor Xa is inactivated by protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). The affinity of this protein for factor Xa is increased 1000-fold by the presence of protein Z, while it does not require protein Z for inactivation of factor XI. Defects in protein Z lead to increased factor Xa activity and a propensity for thrombosis.

The half life of factor X is 40–45 hours.