The Creole case was a slave revolt aboard the American slave ship Creole in November 1841, when the brig was seized by the 128 slaves who were aboard the ship when it reached Nassau in the British colony of the Bahamas where slavery was abolished. The brig was transporting enslaved people as part of the coastwise slave trade in the American South. It has been described as the "most successful slave revolt in US history". Two died in the revolt, an enslaved person and a member of the crew.

The United Kingdom had abolished the slave trade with the Slave Trade Act in 1807, and the practise of slavery throughout the British Empire in 1833. Accordingly, British officials in the Bahamas ruled that the enslaved people on Creole were freed after their arrival in Nassau, if they chose to stay. 19 men who were identified as being responsible for the revolt were imprisoned on charges of mutiny; an Admiralty Court hearing on April 1842 ruled that the men had been illegally held captive as slaves and had the right to use force to gain freedom. The 17 men (two of the prisoners had died in the interim) were released and given their freedom.

When the Creole reached New Orleans in December 1841 with three enslaved women and two enslaved children aboard (who had refused to leave the ship), Southerners were outraged about the loss of property; calls for compensation ensued. Relations between the United States and Britain were strained for a time. The incident occurred during negotiations for the Webster–Ashburton Treaty of 1842 but was not directly addressed. The parties settled on seven crimes qualifying for extradition in the treaty, but they did not include slave revolts. Eventually claims for losses of slaves from Creole and two other American ships transporting enslaved persons were repaid to their owners, along with other claims dating to 1814, in a treaty of 1853 between the United States and Britain, for which an arbitration commission awarded settlements in 1855 against each nation.