In atmospheric science, the pressure gradient (typically of air but more generally of any fluid) is a physical quantity that describes in which direction and at what rate the pressure increases the most rapidly around a particular location. The pressure gradient is a dimensional quantity expressed in units of pascals per metre (Pa/m). Mathematically, it is the gradient of pressure as a function of position. The negative gradient of pressure is known as the force density.

In petroleum geology and the petrochemical sciences pertaining to oil wells, and more specifically within hydrostatics, pressure gradients refer to the gradient of vertical pressure in a column of fluid within a wellbore and are generally expressed in pounds per square inch per foot (psi/ft). This column of fluid is subject to the compound pressure gradient of the overlying fluids. The path and geometry of the column is totally irrelevant; only the vertical depth of the column has any relevance to the vertical pressure of any point within its column and the pressure gradient for any given true vertical depth.