I.
n.
1.
Ulcer, fester, abscess, imposthume, gathering, boil, pustule.
2.
Pain, trouble, grief, affliction, sorrow.
II.
a.
1.
Painful (from inflammation), tender, irritated.
2.
Pained, hurt, grieved, tender, galled, aggrieved, vexed, irritable.
3.
Violent, severe, sharp, afflictive, distressing.
III.
ad.
1.
Intensely, severely, grievously.
2.
Deeply, violently, greatly, profoundly.
3.
Sorely, sadly, grievously, greatly, severely.