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O que (quem) é hypokalemic periodic paralysis - definição
Hypokalemic periodic paralysis
Hypokalemic periodic paralysis (hypoKPP), also known as familial hypokalemic periodic paralysis (FHPP), is a rare, autosomal dominant channelopathy characterized by muscle weakness or paralysis when there is a fall in potassium levels in the blood. In individuals with this mutation, attacks sometimes begin in adolescence and most commonly occur with individual triggers such as rest after strenuous exercise (attacks during exercise are rare), high carbohydrate meals, meals with high sodium content, sudden changes in temperature, and even excitement, noise, flashing lights, cold temperatures and stress.
Periodic paralysis
HUMAN DISEASE
Familial periodic paralysis; Periodic Paralysis; Paralyses, familial periodic; Periodic Paralyses; Periodic paralyses; Familial Periodic Paralysis; Familial periodic paralyses
Periodic paralysis is a group of rare genetic diseases that lead to weakness or paralysis from common triggers such as cold, heat, high carbohydrate meals, not eating, stress or excitement and physical activity of any kind. The underlying mechanism of these diseases are malfunctions in the ion channels in skeletal muscle cell membranes that allow electrically charged ions to leak in or out of the muscle cell, causing the cell to depolarize and become unable to move.
Hyperkalemic periodic paralysis
HUMAN DISEASE
HYPP; Hyperkalemic Periodic Paralysis; Human hyperkalaemic periodic paralysis; Hyperkalaemic periodic paralysis; Paralysis, hyperkalemic periodic; Adynamia Episodica Hereditaria; Familial Hyperkalemic Periodic Paralysis; Gamstorp disease; Gamstorp episodic adynamy; HyperKPP; HyperPP; Primary Hyperkalemic Periodic Paralysis; HyPP
Hyperkalemic periodic paralysis (HYPP, HyperKPP) is an inherited autosomal dominant disorder that affects sodium channels in muscle cells and the ability to regulate potassium levels in the blood. It is characterized by muscle hyperexcitability or weakness which, exacerbated by potassium, heat or cold, can lead to uncontrolled shaking followed by paralysis.
