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etimologia

O que (quem) é inosine - definição

CHEMICAL COMPOUND

Inosine nucleotides; ATC code D06BB05; ATCvet code QD06BB05; ATC code G01AX02; ATCvet code QG01AX02; ATC code S01XA10; ATCvet code QS01XA10; C10H12N4O5

inosine

['?n?(?)si:n]

¦ noun Biochemistry a compound which is formed in the metabolism of purine and is a nucleoside containing ribose.

Origin

early 20th cent.: from Gk is, in- 'fibre, muscle' + -ose² + -ine⁴.

ITPA

PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS

ITPA (gene); Inosine triphosphate pyrophosphatase

Inosine triphosphate pyrophosphatase is an enzyme that in humans is encoded by the ITPA gene, by the rdgB gene in bacteria E.coli and the HAM1 gene in yeast S.

https://en.wikipedia.org/wiki/ITPA

GMP reductase

CLASS OF ENZYMES

EC 1.7.1.7; Inosine-5'-phosphate:NADP+ oxidoreductase (aminating); Gmp reductase

GMP reductase (Guanosine 5'-monophosphate oxidoreductase ) is an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP into IMP.

https://en.wikipedia.org/wiki/GMP_reductase

Wikipédia

Inosine

Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N₉-glycosidic bond. It was discovered in 1965 in analysis of RNA transferase. Inosine is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs.

Knowledge of inosine metabolism has led to advances in immunotherapy in recent decades. Inosine monophosphate is oxidised by the enzyme inosine monophosphate dehydrogenase, yielding xanthosine monophosphate, a key precursor in purine metabolism. Mycophenolate mofetil is an anti-metabolite, anti-proliferative drug that acts as an inhibitor of inosine monophosphate dehydrogenase. It is used in the treatment of a variety of autoimmune diseases including granulomatosis with polyangiitis because the uptake of purine by actively dividing B cells can exceed 8 times that of normal body cells, and, therefore, this set of white cells (which cannot operate purine salvage pathways) is selectively targeted by the purine deficiency resulting from inosine monophosphate dehydrogenase (IMD) inhibition.

https://en.wikipedia.org/wiki/Inosine