The 16550 UART (universal asynchronous receiver/transmitter) is an integrated circuit designed for implementing the interface for serial communications. The corrected -A version was released in 1987 by National Semiconductor. It is frequently used to implement the serial port for IBM PC compatible personal computers, where it is often connected to an RS-232 interface for modems, serial mice, printers, and similar peripherals. It was the first serial chip used in the IBM PS/2 line, which were introduced in 1987.

The part was originally made by National Semiconductor. Similarly numbered devices, with varying levels of compatibility with the original National Semiconductor part, are made by other manufacturers. A UART function that is register-compatible with the 16550 is usually a feature of multifunction I/O cards for IBM PC-compatible computers and may be integrated on the motherboard of other compatible computers.

Replacement of the factory-installed 8250 UART was a common upgrade for owners of IBM PC, XT, and compatible computers when high-speed modems became available. Above 9600 baud, owners discovered that the serial ports of the computers were not able to handle a continuous flow of data without losing characters. Exchange of the 8250 (having only a one-byte received data buffer) with a 16550, and occasionally patching or setting system software to be aware of the FIFO feature of the new chip, improved the reliability and stability of high-speed connections.