The Abbasid Caliphate was the third caliphate to succeed the Islamic prophet Muhammad. It was founded by a dynasty descended from Muhammad's uncle, Abbas ibn Abd al-Muttalib (566–653 CE), from whom the dynasty takes its name. They ruled as caliphs for most of the caliphate from their capital in Baghdad in modern-day Iraq, after having overthrown the Umayyad Caliphate in the Abbasid Revolution of 750 CE (132 AH). The Abbasid Caliphate first centered its government in Kufa, modern-day Iraq, but in 762 the caliph Al-Mansur founded the city of Baghdad, near the ancient Babylonian capital city of Babylon. Baghdad became the center of science, culture and invention in what became known as the Golden Age of Islam. This, in addition to housing several key academic institutions, including the House of Wisdom, as well as a multiethnic and multi-religious environment, garnered it a worldwide reputation as the "Center of Learning".

The Abbasid period was marked by dependence on Persian bureaucrats (such as the Barmakid family) for governing the territories as well as an increasing inclusion of non-Arab Muslims in the ummah (Muslim community). Persian customs were broadly adopted by the ruling elite, and they began patronage of artists and scholars. Despite this initial cooperation, the Abbasids of the late 8th century had alienated both non-Arab mawali (clients) and Persian bureaucrats. They were forced to cede authority over al-Andalus (current Spain and Portugal) to the Umayyads in 756, Morocco to the Idrisids in 788, Ifriqiya and Sicily to the Aghlabids in 800, Khorasan and Transoxiana to the Samanids and Persia to the Saffarids in the 870s, and Egypt to the Isma'ili-Shia caliphate of the Fatimids in 969.

The political power of the caliphs was limited with the rise of the Iranian Buyids and the Seljuq Turks, who captured Baghdad in 945 and 1055, respectively. Although Abbasid leadership over the vast Islamic empire was gradually reduced to a ceremonial religious function in much of the caliphate, the dynasty retained control of its Mesopotamian domain during the rule of Caliph al-Muqtafi and extended into Iran during the reign of Caliph al-Nasir. The Abbasids' age of cultural revival and fruition ended in 1258 with the sack of Baghdad by the Mongols under Hulagu Khan and the execution of al-Musta'sim. The Abbasid line of rulers, and Muslim culture in general, re-centred themselves in the Mamluk capital of Cairo in 1261. Though lacking in political power (with the brief exception of Caliph al-Musta'in of Cairo), the dynasty continued to claim religious authority until a few years after the Ottoman conquest of Egypt in 1517, with the last Abbasid caliph being Al-Mutawakkil III.