Middlewich is a town in the unitary authority of Cheshire East and the ceremonial county of Cheshire, England, 19.2 miles (30.9 km) east of Chester, 2.9 miles (4.7 km) east of Winsford, 5.3 miles (8.5 km) southeast of Northwich and 4.7 miles (7.6 km) northwest of Sandbach. The population at the 2011 Census was 13,595. Middlewich, with Northwich and Winsford, forms part of the Central Cheshire conurbation, with an estimated 2023 population of 130,000.

Middlewich lies at the confluence of three rivers, the Dane, Croco and Wheelock. Three canals also pass through the town, the Shropshire Union, Trent and Mersey, and the Wardle Canal, as well as three major roads, the A533, A54 and A530; Middlewich also has good motorway links to the nearby cities of Manchester and Liverpool. The town's population has doubled since 1970 despite a reduction in the number of manufacturing jobs in salt and textile manufacturing, suggesting that many of the new residents live in Middlewich for reasons other than local employment.

Since 1990 there have been initiatives to increase the volume of tourism into the town, through events such as the annual folk and boat festival, the Roman and Norman festivals, and regular farmers' markets.

In 2014, it was rated one of the most attractive postcode areas to live in England.