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Что (кто) такое RE1-silencing transcription factor - определение
RE1-silencing transcription factor
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
REST (gene); NRSF; Neuron-Restrictive Silencer Factor
RE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein which in humans is encoded by the REST gene, and acts as a transcriptional repressor. REST is expressly involved in the repression of neural genes in non-neuronal cells.
Transcription factor II B
MAMMALIAN PROTEIN FOUND IN HOMO SAPIENS
TFIIB; General transcription factor IIB; GTF2B; TF2B; Tf2b; Transcription Factor IIB; Transcription Factor II B; GTF2B (gene)
Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC) and aids in stimulating transcription initiation. TFIIB is localised to the nucleus and provides a platform for PIC formation by binding and stabilising the DNA-TBP (TATA-binding protein) complex and by recruiting RNA polymerase II and other transcription factors.
Transcription factor
![''lac'' repressor]] binds its target DNA sequence (gold) in the major groove using a [[helix-turn-helix]] motif. Effector molecule binding (green) occurs in the regulatory domain (labeled). This triggers an allosteric response mediated by the linker region (labeled).](https://commons.wikimedia.org/wiki/Special:FilePath/LacI Dimer Structure Annotated.png?width=200 "''lac'' repressor]] binds its target DNA sequence (gold) in the major groove using a [[helix-turn-helix]] motif. Effector molecule binding (green) occurs in the regulatory domain (labeled). This triggers an allosteric response mediated by the linker region (labeled).")
![DNA-binding domains]] of transcription factors](https://commons.wikimedia.org/wiki/Special:FilePath/Transcription factors DNA binding sites.svg?width=200 "DNA-binding domains]] of transcription factors")
PROTEIN THAT BINDS TO DNA AND REGULATES GENE EXPRESSION BY PROMOTING OR SUPPRESSING TRANSCRIPTION
Transcription factors; Basal factor; Upstream transcription factor; Trans-activator; Upstream binding factor; Upstream stimulatory factors; Promoter factor; TFBS; Gene transcription factor; Sequence-specific DNA-binding factor; Transcription factor protein; Signal-sensing domain; Transactivation factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism.
