The Rue de la Loi (French: [ʁy d(ə) la lwa]) or Wetstraat (Dutch), meaning "Law Street", is a major street running through central and eastern Brussels, Belgium, which is famous due to the presence of several notable Belgian and European Union (EU) governmental buildings. The road runs from the Rue Royale/Koningsstraat, in central Brussels, to the Robert Schuman Roundabout in its European Quarter. It forms the first (westerly) part of the N3 road that runs to Aachen, Germany.

The terms Rue de la Loi in French or Wetstraat in Dutch are used metonymically for government in Belgian politics and media because the Belgian Federal Parliament building (Palace of the Nation) stands at the beginning of this street and the office of the Prime Minister is located adjacent to this building, at number 16. It is also where the Council of Ministers holds its meetings.

At the far end, next to the Schuman Roundabout, are the Berlaymont building of the European Commission, the Europa building of the European Council and Council of the European Union, and the Parc du Cinquantenaire/Jubelpark beyond that. Shortly before the roundabout is the exit ramp from the tunnel under the roundabout and Cinquantenaire.