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Что (кто) такое pyroglutamic acid - определение
![[[Acetic acid]], a [[weak acid]], donates a proton (hydrogen ion, highlighted in green) to water in an equilibrium reaction to give the [[acetate]] ion and the [[hydronium]] ion. Red: oxygen, black: carbon, white: hydrogen.](https://commons.wikimedia.org/wiki/Special:FilePath/Acetic-acid-dissociation-3D-balls.png?width=200 "[[Acetic acid]], a [[weak acid]], donates a proton (hydrogen ion, highlighted in green) to water in an equilibrium reaction to give the [[acetate]] ion and the [[hydronium]] ion. Red: oxygen, black: carbon, white: hydrogen.")
Википедия
Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid) is a ubiquitous but little studied natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. The names of pyroglutamic acid conjugate base, anion, salts, and esters are pyroglutamate, 5-oxoprolinate, or pidolate.
It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate, or enzymatically converted by glutaminyl cyclases. This is one of several forms of blocked N-termini which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.
Pyroglutamic acid exists as two distinct enantiomers:
- (2R) or D which happens to be (+) or d
- (2S) or L which happens to be (–) or l
