Lesser, from Eliezer (Hebrew: אֱלִיעֶזֶר‎, Modern: Eli'ezer, Tiberian: ʼĔlîʻézer, "Help/Court of my God"), is a surname. Notable people with the surname include:

• Adolf Lesser (1851–1926), German physician
• Aleksander Lesser (1814–1884), Polish painter and art critic
• Anton Lesser (born 1952), British actor
• Axel Lesser (born 1946), East German cross country skier
• Edmund Lesser (1852–1918), German dermatologist
• Erik Lesser (born 1988), German biathlete
• Gabriele Lesser (born 1960), German historian and journalist
• George Lesser, American musician
• Gerald S. Lesser (1926–2010), American psychologist
• Henry Lesser (born 1963), German footballer
• J Lesser (born 1970), American musician
• Len Lesser (1922–2011), American actor
• Louis Lesser (born 1916), American real estate developer
• Matt Lesser, Connecticut politician
• Mike Lesser (born 1943), British mathematical philosopher and political activist
• Milton Lesser or Stephen Marlowe (1928–2008), American author
• Norman Lesser (1902–1985), Anglican bishop and Archbishop of New Zealand
• Otto Lesser (1830–1887), German astronomer
• Rika Lesser (born 1953), American poet
• Robert Lesser (born 1942), American actor
• Rosa Lesser, Austrian luger
• Ryan Lesser, Rhode Island video game designer
• Sam Lesser or Sam Russell (1915–2010), British journalist and Spanish Civil War veteran
• Sol Lesser (1890–1980), American film producer
• Stephen A. Lesser (born 1944), American architect
• Virginia Lesser, American statistician
• Wendy Lesser (born 1952), American author, editor and critic
• Werner Lesser (1932–2005), East German ski jumper

Lesser is also a given name. Notable people with the given name include:

• Lesser Samuels (1894–1980), Hollywood screenwriter
• Lesser Ury (1861-1931), German Impressionist painter and printmaker