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estrogen$26049$ - перевод на Английский
![coronary heart disease]] with HRT vary depending on age and time since menopause.](https://commons.wikimedia.org/wiki/Special:FilePath/Blausen 0257 CoronaryArtery Plaque.png?width=200 "coronary heart disease]] with HRT vary depending on age and time since menopause.")
.svg?width=200 "Symptoms of menopause")
![woman's hormone levels]]](https://commons.wikimedia.org/wiki/Special:FilePath/615 Age and Bone Mass.jpg?width=200 "woman's hormone levels]]")
![Size of the [[vaginal canal]] before and after menopause, demonstrating vaginal [[atrophy]]](https://commons.wikimedia.org/wiki/Special:FilePath/Vaginal Canal Normal vs. Menopause.png?width=200 "Size of the [[vaginal canal]] before and after menopause, demonstrating vaginal [[atrophy]]")
Определение
Википедия
Estrogen insensitivity syndrome (EIS), or estrogen resistance, is a form of congenital estrogen deficiency or hypoestrogenism which is caused by a defective estrogen receptor (ER) – specifically, the estrogen receptor alpha (ERα) – that results in an inability of estrogen to mediate its biological effects in the body. Congenital estrogen deficiency can alternatively be caused by a defect in aromatase, the enzyme responsible for the biosynthesis of estrogens, a condition which is referred to as aromatase deficiency and is similar in symptomatology to EIS.
EIS is an extremely rare occurrence. As of 2016, there have been three published reports of EIS, involving a total of five individuals. The reports include a male case published in 1994, a female case published in 2013, and a familial case involving two sisters and a brother which was published in 2016.
EIS is analogous to androgen insensitivity syndrome (AIS), a condition in which the androgen receptor (AR) is defective and insensitive to androgens, such as testosterone and dihydrotestosterone (DHT). The functional opposite of EIS is hyperestrogenism, for instance that seen in aromatase excess syndrome.
