Comic book price guides are generally monthly, quarterly, or yearly publications which detail the changes in the resale value of a comic over a period of time. Price guides are also important tools for collectors looking to sell their collection or determine their collection’s worth for insurance purposes.

Each collector will have his or her own preference regarding which authority to follow, but popular and respected guides have included The Official Overstreet Comic Book Price Guide, Comics Buyer's Guide magazine, Wizard Magazine, the Comics Buyer's Guide Standard Catalog of Comic Books, and Human Computing’s ComicBase, an inventory/databasing software program. Popular online price guides include comicbookrealm.com (free), ComicsPriceGuide.com (free and paid services), RarityGuide (free and paid), and GPAnalysis.com specifically for CGC (certified) Comics (paid). Online and print price guides will have their own discrepancies, so a combination of several sources is often used by collectors to arrive at an accurate estimated value. Checking completed auctions at eBay and Heritage is also very helpful.

Although many price guides come and go, long-standing publications such as Overstreet (which has been running for over 35 years) or the more recent Standard Catalog of Comic Books, have long since become inextricable elements of comic collection history. These guides are popular resources for collectors and enthusiasts seeking information on anything from storylines to writers and artists to the original cover price of a comic. Grand Comics Database and comicbookrealm.com, in particular, offer users the ability to quickly search for characters by appearances and deaths. The Big Comic Book DataBase combines a searchable database of per issue character and creator information and a linked price guide.

The advent of certification enabled increased liquidity of comic books by removing disputes over grading and by disclosing restoration, and accelerated sales of comic books through online auction sites such as eBay or Heritage Auction Galleries. Certification is also valued by some comic price guide providers, as certification leaves the perception of removing the uncertainty about the actual grade of the comic book being sold, although, because books that are certified are graded by numerous different individuals, the dependability of these services is not universally agreed upon. Individual and/or aggregated reports of certified comic book sales are available online.